![]() ![]() Furthermore, because babies with congenital anomalies place significant economic, social, and cultural burden on families and societies, the early detection of such defects during pregnancy can prevent the birth of children with disabilities ( 3). ![]() The syndrome is a common genetic cause of intellectual disabilities worldwide, and many DS patients around the world face a variety of additional health issues, including heart defects, hematopoietic disorders, and early-onset Alzheimer disease ( 2). Trisomy 21, called Down syndrome (DS), is one of the most common clinical syndromes, with a prevalence of one in every 800 - 1000 live births ( 1). Although an advanced maternal age is associated with a higher prevalence of DS, clinicians should recommend FTS as the first-line screening method regardless of maternal age.ĭown Syndrome Prenatal Diagnosis Maternal Age Maternal Serum Screening Tests 1. First-trimester screening is an effective method for estimating the risk of DS in women under or over 35 years of age.
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